Barbarian observes:
Understand, every favorable mutation is a mistake in transcription, and although most mistakes do little (and a few are harmful), some of them do turn out to be favorable as you suggest. And those tend to persist, because they give the recipient a leg up on surviving long enough to leave offspring.
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Statistically speaking, random changes must be 99.999...% harmful.
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Sounds interesting. Let's see your numbers as they relate to mutations. Here's a heads-up, Stipe; almost all of us have a few mutations. Few of them have any perceptible affect on fitness. One amino acid in a protein of hundreds of amino acids is unlikely to do very much, unless it's in a critical spot. Remember when I suggested you learn about it before you told us about it? This is why.
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The ones that do nothing are most likely harmful without immediately noticeable consequences.
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So let's see your evidence for that. Should be interesting.
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If a random change is not harmful (immediately or otherwise) then that is good evidence the change was intended and not a mistake.
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And your evidence for that is...?
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