An atheist would give you adulterated Rat Virus to cure your cancer...
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Look, scientists are nuts. Virologists, on the other hand, are certifiably insane. As Hedwig would say, virologists make the strangest things seem suddenly routine. Yesterdays absurd future technology (GENE THERAPY!) is now something as miraculous as curing genetic diseases, and as mundane as an anti-smoking therapy.
Todays insane idea?
Using mouse and ratparvoviruses to treat human cancers.
This is not some lone mad scientists mad idea– Though this info was news to me, this approach is being explored world-wide, and is already in clinical trials for glioblastoma multiform. Yeah, read that Wikipedia article on glioblastoma multiform
most common and most aggressive malignant primary brain tumor
52% of all functional tissue brain tumor cases and 20% of all intracranial tumors
Most glioblastoma tumors appear to be sporadic, without any genetic predisposition.
It is very difficult to treat glioblastoma due to several complicating factors:
The tumor cells are very resistant to conventional therapies
The brain is susceptible to damage due to conventional therapy
The brain has a very limited capacity to repair itself
Many drugs cannot cross the blood-brain-barrier to act on the tumor
The median survival time from the time of diagnosis without any treatment is 3 months, but with treatment survival of 1–2 years is common.
We have no idea what causes it. Traditional therapies dont work because its the brain. And once you are diagnosed you are pretty much screwed.
Enter mouse and rat parvoviruses.
Though you all are probably most familiar with the canine form of parvovirus that is extremely deadly to dogs and puppies, apparently, there are genes in mouse and rat parvovirus that make them a) oncolytic (blow up cancers) and b) oncosuppressive (keep tumors from growing).
When scientists used the rodent parvoviruses against some cell lines in the lab (functionally ‘cancers’) and some animal models of cancer, the tumors stopped growing and/or were killed.
SWEET!
Well there is a good thing and a bad thing about using rodent parvoviruses as cancer therapies. The good thing is that the viruses dont replicate in humans, which means it would be a pretty safe therapy (especially considering the radiation/chemo/surgery alternatives). The bad thing is that the viruses dont replicate in humans, which means you cant use them to infect human cancers. They wont.
Solution?
Go to our ol buddy, Adeno Associated Viruses. Stuff em full of rodent parvovirus DNA. Have the AAV deliver the rodent parvovirus genome (we know AAV loves human cells), the parvovirus genome makes all the anti-cancer proteins, but cant make infectious virus (but wouldnt infect humans anyway), dead tumor.
OF COURSE!
LOL!
I know Im saying this cavalierly, but generating an AAV/parvovirus chimera is not simple. Viruses are not interchangeable Lego blocks you can take apart and click together. A lot of effort (a lot of failure) went into generating this chimeric virus on the front end.
But it was worth the effort– the expected result would be that the chimeric AAV/parvovirus could get into tumors the rodent parvovirus could not get into, and the chimera could slow down/kill tumors AAV couldnt slow down/kill.
It did just that.
And more.
The chimera did not just take the good features from its parental viruses. The new virus was better than its ‘parents’ at executing the desired actions– more cell lysis and lowered cell viability in the tumor cell lines than the parents. The sum is greater than the parts.
Rat viruses as a putative cancer therapy. An option for when there are no options, like for glioblastoma multiform now, might be standard therapy in relatively short order.
Virologists are nuts.
And we are all reaping the benefits of their insanity.
Of course, with all this behind the scenes experimenting worldwide,
we might also shortly reap the downside of their insanity too...
"But if anyone, even an angel from heaven,
were to preach any other gospel than that of
Jesus the Christ, crucified, buried, and
raised from the dead by God the Father,
to deliver us from this present evil world,
let that false preacher be accursed.' (Gal 1:1-4,8-9)
Some of the comments from other medical personnel...
Quote:
I get a mental picture of them as Doctor Frankenstein lopping off parts of this, and parts of that, stitching them together, hitting them with a little lightning and the sound of loud maniacal laughter as their viruses come to life and begin to do their bidding. But doing it all on a diminutive scale.
Quote:
Any details on the human trial? The BBB isn’t just good at keeping drugs out of the brain; it does a pretty good job of keeping viruses out as well. I wonder how they got around that (intercranial injection?)
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Not much weirder than using Salmonella as either an anti-tumor agent (both as vector for drug delivery or as direct agent) or as a vaccine delivery system. Both techniques are under very active investigation at the moment.
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Oh man, there were some recent meeting minutes of an FDA committee where they were discussing something along these lines, it was wild stuff. It was kind of depressing though since the authors were getting called out for making weasel-word statements on things being ‘likely’, ‘less likely’, etc.
Discussion of Human Gene Transfer Protocol #0904-976: A Phase I Ascending-Dose Trial of the Safety and Tolerability of Toca 511 in Patients with Recurrent Glioblastoma Multiforme http://oba.od.nih.gov/oba/RAC/meetin...utes_06-09.pdf (bottom of pdf p. 29 is where discussion starts)
Creeped out yet?
"But if anyone, even an angel from heaven,
were to preach any other gospel than that of
Jesus the Christ, crucified, buried, and
raised from the dead by God the Father,
to deliver us from this present evil world,
let that false preacher be accursed.' (Gal 1:1-4,8-9)
Next thing you know they'll be injecting fungus products into our bodies to cure infections.
Of course only the sexually promiscuous and those who
won't keep the Food Laws in the Bible will be needing that.
"But if anyone, even an angel from heaven,
were to preach any other gospel than that of
Jesus the Christ, crucified, buried, and
raised from the dead by God the Father,
to deliver us from this present evil world,
let that false preacher be accursed.' (Gal 1:1-4,8-9)
Of course only the sexually promiscuous and those who
won't keep the Food Laws in the Bible will be needing that.
Right! Nobody else gets pneumonia, a strep infection, or has infected wounds. Those are all contracted solely from eating the wrong food or sleeping with the wrong people.
Location: A spacious corner office overlooking the River Phlegethon
Rep Power: 50224
Atheist
More right than left
Slogan/motto:
"Do what thou wilt" shall be the hole in the floor.
Reputation:
July 24th, 2012, 11:13 AM
Quote:
Originally Posted by chair
Right! Nobody else gets pneumonia, a strep infection, or has infected wounds. Those are all contracted solely from eating the wrong food or sleeping with the wrong people.
That's how reality works on Planet Nazaroo!
"If builders built buildings the way programmers wrote programs, then the first woodpecker that came along would destroy civilization."
Right! Nobody else gets pneumonia, a strep infection, or has infected wounds. Those are all contracted solely from eating the wrong food or sleeping with the wrong people.
Sadly, even being in the same room with dirty losers
can get a squeeky clean God-fearing holy man contaminated with contagious shiite.
I recommend not even breathing the same air.
Fact is, pneumonia and strep aren't magical entities that appear out of nothing,
as brain-stunted evolutionists would have you believe.
Louis Pasteur (1822-1895)
" He showed that food spoils because of microorganisms
and invented pasteurization, which was originally used
to prevent wine and beer from souring. If that wasn't enough,
he also came up with a rabies vaccine. "
Louis Pasteur proved long ago that germ life DOESN'T spontaneously generate,
but is transmitted via VECTORS,
like filthy Calvinists who don't follow the food laws,
and associate with unclean animals like cats, dogs, and rodents.
Quote:
Toxoplasmosis is a parasitic disease caused by the protozoanToxoplasma gondii.[1] The parasite infects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. The parasite spreads by the ingestion of infected meat or the feces of an infected cat, or by vertical transmission from mother to fetus.
From one-third to half of the world's human population is estimated to carry a Toxoplasma infection.[3][4] The Centers for Disease Control and Prevention notes that overall seroprevalence in the United States as determined with specimens collected by the National Health and Nutritional Examination Survey (NHANES) between 1999 and 2004 was found to be 10.8%, with seroprevalence among women of childbearing age (15 to 44 years) at 11%.[5] Another study placed seroprevalence in the U.S. at 22.5%.[4] The same study claimed a seroprevalence of 75% in El Salvador.[4] A sample of 273 people in rural France was measured at 47% prevalence.[6]
During the first few weeks after exposure, the infection typically causes a mild, flu-like illness or no illness. Thereafter, the parasite rarely causes any symptoms in otherwise healthy adults. However, those with a weakened immune system, such as AIDS patients or pregnant women, may become seriously ill, and it can occasionally be fatal. The parasite can cause encephalitis (inflammation of the brain) and neurologic diseases, and can affect the heart, liver, inner ears, and eyes (chorioretinitis). Recent research has also linked toxoplasmosis with brain cancer, attention deficit hyperactivity disorder, obsessive compulsive disorder, and schizophrenia.[7][8]
And please, don't spray your dirty saliva on me while you're talking.
In fact, let me get my Hazmat suit, before we begin this. Cootyman.
"But if anyone, even an angel from heaven,
were to preach any other gospel than that of
Jesus the Christ, crucified, buried, and
raised from the dead by God the Father,
to deliver us from this present evil world,
let that false preacher be accursed.' (Gal 1:1-4,8-9)
Last edited by Nazaroo; July 24th, 2012 at 11:55 AM.
"But if anyone, even an angel from heaven,
were to preach any other gospel than that of
Jesus the Christ, crucified, buried, and
raised from the dead by God the Father,
to deliver us from this present evil world,
let that false preacher be accursed.' (Gal 1:1-4,8-9)
Location: A spacious corner office overlooking the River Phlegethon
Rep Power: 50224
Atheist
More right than left
Slogan/motto:
"Do what thou wilt" shall be the hole in the floor.
Reputation:
July 24th, 2012, 03:32 PM
Quote:
Originally Posted by Nazaroo
Gerald's House?:
If so, I think your Avatar is most appropriate...
If I say "no" you'll just say I'm lying, because that's what Filthy Unbelievers™ do...when they're not hatching a plot to slip a little bit of ground-up pork or raisins into your food...
Just to see you go through the prescribed atonement and cleansing rituals would be comedy gold.
"If builders built buildings the way programmers wrote programs, then the first woodpecker that came along would destroy civilization."
Just to see you go through the prescribed atonement and cleansing rituals would be comedy gold.
The first thing I do is take off all my clothes, soak them in salt water,
And go for my ritual bath in the clean (uninfested by people) waters leading off my back veranda:
I'm surprised you remembered the raisins.
How did that happen?
"But if anyone, even an angel from heaven,
were to preach any other gospel than that of
Jesus the Christ, crucified, buried, and
raised from the dead by God the Father,
to deliver us from this present evil world,
let that false preacher be accursed.' (Gal 1:1-4,8-9)
An atheist would give you adulterated Rat Virus to cure your cancer... -
July 24th, 2012, 01:00 AM
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